Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands. Department of Bioinformatics - BiGCaT, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands. Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands. Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands. Department of Epidemiology, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. Nestlé Institute of Health Sciences, Lausanne, Switzerland. INSERM, UMR1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France. Paul Sabatier University, Toulouse, France. Laboratory of Clinical Biochemistry, Toulouse University Hospitals, Toulouse, France. Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands e.blaak@maastrichtuniversity.nl.